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Insulin degludec
CAS No. 844439-96-9
Insulin degludec ( —— )
产品货号. M25046 CAS No. 844439-96-9
德谷胰岛素是一种超长效胰岛素，用于治疗 1 型和 2 型达贝特引起的高血糖。德谷胰岛素对胰岛素受体具有结合效率，IC50 值为 19.59 nM/L。德谷胰岛素可用于1型和2型糖尿病的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2682 | 有现货 |
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| 10MG | ￥4464 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Insulin degludec
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述德谷胰岛素是一种超长效胰岛素，用于治疗 1 型和 2 型达贝特引起的高血糖。德谷胰岛素对胰岛素受体具有结合效率，IC50 值为 19.59 nM/L。德谷胰岛素可用于1型和2型糖尿病的研究。
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产品描述Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM/L for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM/L.Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells.
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体外实验Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM.Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells. Western Blot Analysis Cell Line:HL-1 cardiomyocytes Concentration:200 nM Incubation Time:0-60 min Result:Decreased the level of Akt phosphorylation after 5 and 10min treatment.
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体内实验Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. Animal Model:Male Swiss mice with diabetes Dosage:5 U/kg Administration:Subcutaneous injection; 5 U/kg once daily for 30 days Result:Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
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同义词——
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通路Tyrosine Kinase
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靶点Insulin Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number844439-96-9
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分子量——
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分子式——
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纯度>98% (HPLC)
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溶解度0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 2 with 0.1 M HCL)
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SMILESN/A
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bataglini C, et al. Insulin degludec and glutamine dipeptide modify glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. J Appl Biomed. 2021 Dec;19(4):210-219.
2. Hartmann T, et al. Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function. Cardiovasc Diabetol. 2016 Jul
产品手册
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Insulin degludec
德谷胰岛素是一种超长效胰岛素，用于治疗 1 型和 2 型达贝特引起的高血糖。德谷胰岛素对胰岛素受体具有结合效率，IC50 值为 19.59 nM/L。德谷胰岛素可用于1型和2型糖尿病的研究。
